产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

HDAC7 (G932) polyclonal antibody（KU）

货号: BS1166

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1166

Product Name :HDAC7 (G932) polyclonal antibody（KU）

Swiss-Prot :Q8WUI4

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC7 is a histone deacetylase that interacts with the adaptor mSin3A. The interaction of HDAC7 with mSin3A suggests the association of multiple repression complexes of transcription factors.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HDAC7 (G932) polyclonal antibody detects endogenous levels of HDAC7 protein.

BiowMW :~ 105 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Notch Signaling,Cell Cycle Control G1 S Checkpoint,Epigenetic Writers and Erasers of Histone H3,Epigenetic Writers and Erasers of Histones H2A H2B and H4,

Alternative Name :Histone deacetylase 7; HDAC 7; HDAC-7

Immunogen :Synthetic peptide, corresponding to amino acids 901-950 of Human HDAC7.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of HDAC7 (G932) pAb at 1:500 dilution Lane1:C6 whole cell lysate(40ug) Lane2:3T3-L1 whole cell lysate(40ug) Lane3:Hela whole cell lysate(40ug) Lane4:MCF-7 whole cell lysate(40ug) Lane5:U-87MG whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of HDAC7 (G932) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.