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HDAC6 (H1203) polyclonal antibody（KU）

货号: BS1165

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1165

Product Name :HDAC6 (H1203) polyclonal antibody（KU）

Swiss-Prot :Q9UBN7

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :HDAC6 is a member of the class II mammalian histone deacetylases. Human HDAC6 is composed of 1215 amino acid residues. It possesses two separate putative catalytic domains. Both catalytic domains are fully functional HDACs and contribute independently to the overall activity of HDAC6 protein. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. The expression of HDAC6 is tightly linked to the state of cell differentiation. HDAC6 may participate in coordinating expression of a group of genes involved in the remodelling of chromatin during cell differentiation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HDAC6 (H1203) polyclonal antibody detects endogenous levels of HDAC6 protein.

BiowMW :~ 131, 160 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Notch Signaling,Nuclear Receptor Signaling,Cell Cycle Control G1 S Checkpoint,

Alternative Name :Histone deacetylase 6; HD6; HDAC 6; KIAA0901; JM21

Immunogen :Synthetic peptide, corresponding to the C-terminual of Human HDAC6.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of HDAC6 (H1203) pAb at 1:500 dilution Lane1:PC12 whole cell lysate(40ug) Lane2:BV2 whole cell lysate(40ug) Lane3:A375 whole cell lysate(40ug) Lane4:MCF-7 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of HDAC6 (H1203) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Maternal low-protein diet causes epigenetic deregulation of HMGCR and CYP7α1 in the liver of weaning piglets

JournalJournal Of Nutritional Biochemistry

ApplicationWB

IF6.048

SpeciesPig

PMID22444501
Cytoplasmic Retention of a Nucleocytoplasmic Protein TBC1D3 by Microtubule Network Is Required for Enhanced EGFR Signaling

JournalPLoS One

ApplicationWB

IF2.74

SpeciesHuman

PMID