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CHOP (K121) polyclonal antibody

货号: BS1136

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1136

Product Name :CHOP (K121) polyclonal antibody

Swiss-Prot :P35638

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :GADD153 is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP alpha and beta. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP GADD153 dimer gains binding activity to other non classical C/EBP stress related targets. Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of GADD153 inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CHOP (K121) polyclonal antibody detects endogenous levels of CHOP protein.

BiowMW :~ 19,27 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Signaling Pathways Activating p38 MAP Kinase,

Alternative Name :DNA damage-inducible transcript 3 protein; DDIT-3; C/EBP zeta; C/EBP-homologous protein; CHOP; C/EBP-homologous protein 10; CHOP-10; CCAAT/enhancer-binding protein homologous protein; Growth arrest and DNA damage-inducible protein GADD153; DDIT3; CHOP; CHOP10; GADD153

Immunogen :Synthetic peptide, corresponding to amino acids 100-150 of Human CHOP.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CHOP (K121) pAb at 1:500 dilution Lane1:A375 whole cell lysate(40ug) Lane2:HCT116 whole cell lysate(40ug) Lane3:The Kidney tissue lysate of Mouse(40ug) Lane4:PC12 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of CHOP (K121) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

LncRNA GAS5 suppresses ER stress‑induced apoptosis and inflammation by regulating SERCA2b in HG‑treated retinal epithelial cell

JournalMolecular Medicine Reports

ApplicationWB

IF2.1

SpeciesHuman

PMID32467994
HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway

JournalJournal Of Physiology And Biochemistry

ApplicationWB

IF4.158

SpeciesRat

PMID35315506
Administration of the GLP-1 receptor agonist exenatide in rats improves functional recovery after spinal cord injury by reducing endoplasmic reticulum stress

JournalIBRO Neuroscience Reports

ApplicationWB

IF1.5

SpeciesRat

PMID37822517
Berberine alleviates ovarian tissue damage in mice with hepatolenticular degeneration by suppressing ferroptosis and endoplasmic reticulum stress

JournalJournal of Integrative Medicine-JIM

ApplicationWB

IF4.8

SpeciesMouse

PMID38853116
Asiatic Acid Alleviates LPS-Induced Pyroptosis and Endoplasmic Reticulum Stress-Mediated Apoptosis via Inhibiting the HMGB1/TLR4/NF-κB Pathway in Broiler Hepatocytes

Journal10.1111/jpn.14070

Application

IF2.2

Species

PMID39543935