Product Name :Ezrin (S539) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :Ezrin, Moesin and Radixin belong to a family of highly homologous Actinassociated proteins that are localized just beneath the plasma membrane. The proteins are believed to be involved in the mediation of interactions between cytoskeletal and membrane proteins. Ezrin serves as a major cytoplasmic substrate of various protein-tyrosine kinases, including the epidermal growth factor receptor. Ezrin has also been identified as a cAMP-dependent protein kinase (A-kinase) anchoring protein and designated AKAP78. Moesin and Radixin share over 70% homology with Ezrin and are coexpressed within various cell types. Despite the high degree of homology, the three proteins exhibit a distinct receptor-specific pattern of phosphorylation.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Ezrin/Villin-2 (S539) polyclonal antibody detects endogenous levels of Ezrin/Villin-2 protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Contribution of ECM and Cytoskeletal Factors to EMT,B cell receptor signaling,
Alternative Name :Cytovillin; Villin-2; Villin2; p81; EZR; VIL2
Immunogen :Synthetic peptide, corresponding to amino acids 500-550 of Human Ezrin.
Modification :Unmodification
