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ERα (L100) polyclonal antibody

货号: BS1114
价格 1140
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS1114
Product Name :ERα (L100) polyclonal antibody
Swiss-Prot :P03372
Host :Rabbit
Reactivity :Human,Mouse,Rat
Applications :WB IHC
Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200
Background :Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERα and ERβ may be regulated by distinct mechanisms even though they share many functional characteristics.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Estrogen Receptor-α (L100) polyclonal antibody detects endogenous levels of Estrogen Receptor-α protein.
BiowMW :~ 66 kDa
Note :For research use only, not for use in diagnostic procedure.
Pathway :Nuclear Receptor Signaling,
Alternative Name :Estrogen receptor; ER-alpha; ER; ESR1; ESR; NR3A1
Immunogen :Synthetic peptide, corresponding to amino acids 61-110 of Human ERα.
Conjugate :Unconjugated
Modification :Unmodification
Western blot (WB) analysis of ERα (L100) polyclonal antibody at 1:500 dillution Lane1:MCF-7 whole cell lysate(40μg) Lane2:NIH-3T3 whole cell lysate(40μg) Lane3:H9C2 whole cell lysate(40μg)
Immunohistochemistry (IHC) analyzes of ERα (L100) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
  • Concomitant high expression of ERα36, EGFR and HER2 is associated with aggressive behaviors of papillary thyroid carcinomas
    JournalScientific Reports
    ApplicationIHC
    IF3.998
    SpeciesHuman
  • Expression of GALNT8 and O-glycosylation of BMP receptor 1A suppress breast cancer cell proliferation by upregulating ERα levels
    JournalBiochimica Et Biophysica Acta-General Subjects
    ApplicationWB
    IF3.77
    SpeciesHuman

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com