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EGFR (S1064) polyclonal antibody

货号: BS1101

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1101

Product Name :EGFR (S1064) polyclonal antibody

Swiss-Prot :P00533

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Ligand binding promotes the internalization of EGFR via Clathrin-coated pits and its subsequent degradation in response to its intrinsic tyrosine kinase. EGFR is involved in organ morphogenesis and maintenance and repair of tissues, but upregulation of EGFR is associated with tumor progression. The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion and metastasis. Abrogation of EGFR results in cell cycle arrest, apoptosis or dedifferentiation of cancer cells, suggesting that EGFR may be an effective therapeutic target.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :EGFR (S1064) polyclonal antibody detects endogenous levels of EGFR protein

BiowMW :~ 175 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :ErbB HER Signaling,

Alternative Name :Epidermal growth factor receptor; EC=2.7.10.1; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; ERBB; ERBB1; HER1; EGFR

Immunogen :Synthetic peptide, corresponding to amino acids 1041-1090 of Human EGFR.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of EGFR (S1064) polyclonal antibody at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:sp2/0 cell lysate

Immunohistochemistry (IHC) analyzes of EGFR (S1064) pAb in paraffin-embedded human breast carcinoma tissue.

MicroRNA‑27a functions as a tumor suppressor in renal cell carcinoma by targeting epidermal growth factor receptor

JournalOncology Letters

ApplicationWB

IF2.311

SpeciesMouse

PMID27313769