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Claudin-7 (P202) polyclonal antibody（KU）

货号: BS1070

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1070

Product Name :Claudin-7 (P202) polyclonal antibody（KU）

Swiss-Prot :O95471

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF IP

Application_all :WB: 1:500~1:1000 IHC/IF: 1:50~1:200 IP: 1:50~1:200

Background :The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. mRNA studies indicate that claudin-7 is specifically expressed in mouse lung and kidney, but not in heart, brain, spleen, liver, skeletal muscle or testis. The gene encoding human claudin-7 maps to chromosome 17p13.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Claudin 7 (P202) polyclonal antibody detects endogenous levels of Claudin 7 protein.

BiowMW :~ 23 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Claudin 7; Claudin7; CLDN-7; CLDN7; CEPTRL2; CPETRL2

Immunogen :Synthetic peptide, corresponding to amino acids 171-220 of Human Claudin-7.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Claudin-7 (T202) polyclonal antibody at 1:500 dilution Lane1:HCC827 whole cell lysate(40ug) Lane2:The Lung tissue lysate of Mouse(40ug) Lane3:The Lung tissue lysate of Rat(40ug) Lane4:A549 whole cell lysate(40ug) Lane5:L02 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Claudin-7 (P202) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Immunoprecipitation of Hela cell lysate using Claudin-7 (P202) pAb (Sepharose Bead Conjugate) #BD0048(lane 2 and lane 3) and Nonspecific IgG Control (Sepharose Bead Conjugate) #BD0048 (lane 4 and lane 5 ) .Lane 1 is 30% input. The western blot was probed using Claudin-7 (P202) #BS1070. “↑”（supernatant）; “↓(deposition）

Expression patterns of tight junction proteins in porcine major salivary glands: a comparison study with human and murine glands

JournalJournal Of Anatomy

ApplicationIF

IF2.61

SpeciesHuman,Mouse,Pig

PMID29851087
Disruption of tight junctions contributes to hyposalivation of salivary glands in a mouse model of type 2 diabetes

JournalJournal Of Anatomy

ApplicationWB

IF2.013

SpeciesMouse

PMID32374057
Alteration of tight junctions during botulinum toxin type A-inhibited salivary secretion

JournalORAL DISEASES

ApplicationWB,IF

IF3.511

SpeciesMouse

PMID35472254