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APC (Q2829) polyclonal antibody（KU）

货号: BS1017

价格：￥ 660

货期：现货（1-2个工作日）

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No. :BS1017

Product Name :APC (Q2829) polyclonal antibody（KU）

Swiss-Prot :P25054

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :IHC

Application_all :IHC: 1:50~1:200

Background :Adenomatous polyposis coli (APC) is a protein that plays a critical role in several cellular processes. APC is a tumor suppressor, regulates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division and associates with other proteins involved in cell attachment and signaling. APC regulates ß-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :APC (Q2829) polyclonal antibody detects endogenous levels of APC protein.

BiowMW :~ 310 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Microtubule Dynamics,Contribution of Soluble Factors to EMT,

Alternative Name :Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5; APC; DP2.5

Immunogen :Synthetic peptide, corresponding to the C-terminal of Human APC.

Conjugate :Unconjugated

Modification :Unmodification

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