Product Name :SMYD2 (L148) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
Background :SMYD2 (SET and MYND domain containing 2), also known as KMT3C, HSKM-B or ZMYND14, is a 433 amino acid protein that contains one SET domain and one MYND-type zinc finger. Expressed at high levels in liver,heart, kidney, ovary and brain, SMYD2 functions as a lysine methyltransferase that, via methylation of p53, may play a role in repressing p53-mediated transcriptional regulation. The gene encoding MSYD2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :SMYD2 (L148) polyclonal antibody detects endogenous levels of SMYD2 protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Epigenetic Writers and Erasers of Histone H3,
Alternative Name :KMT3C; HSKM-B; N-lysine methyltransferase SMYD2
Immunogen :Synthetic peptide, corresponding to amino acids 116-164 of Human SMYD2.
Modification :Unmodification
