中国 EN 400-660-9091

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Biotinylated Anti-DXD&Exatecan Antibody, Mouse IgG1, Avitag™ (MALS verified)

货号: BS66194M
价格
货期 现货(1-2个工作日)
No. :BS66194M
Product Name :Biotinylated Anti-DXD&Exatecan Antibody, Mouse IgG1, Avitag™ (MALS verified)
Host :Mouse
Applications :ELISA
Application_all :ELISA 1-5000 ng/mL
Background :Dxd (Exatecan ADC derivative) is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 uM for targeting ADCs (DS-8201A). Dxd was cytotoxic to human tumor cell lines KPL-4, NCI-N87 and SK-BR, 3 and the IC50s of MDA-MB-468 was 1.43 NM-4.07 nM, while lgGADC (Dxd as payload) had no inhibitory effect on HER2 expression in the 4 cell lines. DS8201a (Dxd as payload) had a significant inhibitory effect on HER2-positive KPL-4 and NCI cell lines N87 and SK-BRwith IC50 values of 26.8, 25.4 and 6.7 ng/mL, respectively, but had no inhibitory effect on MDA MB-468 (IC50, > 10000 - mL). HRP-anti-DXD-antibody is a conjugation product of HRP and anti-DXD-antibody. It can be used in PK, PD analysis and ELISA.
Product :Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Purification&Purity :Protein A purified / Protein G purified
Storage&Stability :-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Specificity :Specifically recognizes the target-DXD.
Note :For research use only, not for use in diagnostic procedure.
Immunogen :DXD
Conjugate :Unconjugated
Modification :Biotinylated
Immobilized Human Her2, His Tag at 1 μg/mL, add Trastuzumab Deruxtecan in the 100% Human Serum and then add Biotinylated Anti-DXD&Exatecan Antibody, Mouse IgG1, Avitag at 0.05 μg/mL. Detection was performed using HRP-conjugated Streptavidin (QC tested).
Immobilized Trastuzumab Deruxtecan at 1 μg/mL (100 μL/well) can bind Biotinylated Anti-DXD&Exatecan Antibody, Mouse IgG1, Avitag with a linear range of 0.5-8 ng/mL (Routinely tested).

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com