Product Name :HNF1A Recombinant Rabbit mAb (KU)
Swiss-Prot :P20823, P22361, P15257
Reactivity :Human, Mouse, Rat
Applications :WB, IHC, ICC/IF, FC
Background :The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
