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IRP-1 (N707) polyclonal antibody

货号: BS1761

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1761

Product Name :IRP-1 (N707) polyclonal antibody

Swiss-Prot :P21399

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :IHC

Application_all :IHC: 1:50~1:200

Background :Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE–BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IRP-1 (N707) polyclonal antibody detects endogenous levels of IRP-1 protein.

BiowMW :~ 98 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; ACO1; IREB1

Immunogen :Synthetic peptide, corresponding to amino acids 680-720 of Human IRP-1.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry (IHC) analyzes of IRP-1 (N707) pAb in paraffin-embedded human colorectal cancer carcinoma tissue at 1:100.